The application of drug loading and drug release characteristics of two-dimensional nanocarriers for targeted treatment of leukemia

The development of bioinformatics technology has enabled nanomedicine to play a significant role in drug delivery systems. Its low toxicity, high efficiency, and controllable release advantages make it have good application effects. Moreover, common targeted therapeutic formulations weak stability malignant tumor leukemia, their effects are limited. Therefore, based on the characteristics black phosphorus two-dimensional nanomedicine, experimental designs were conducted its nanosheet preparation, polyethylene glycol modification, anti-tumor loading. Experimental analysis was also characterization ability, release, therapy nanomedicine. results show that (PEG) modified crystals (BP) nanoparticles can effectively improve negative electricity, relatively stable photothermal properties. doxorubicin hydrochloride (DOX) loaded analyzed. It found maximum efficiency BP-PEG-DOX higher than BP-DOX at pH 5 7.5 (12.13% > 7.69%, 29.46% 28.69%). rates BP-PEG-DOX-NIR reached 33.23% 28.67% temperatures 35°C 45°C, with differences over 10% compared non laser group. nano particles PEG treated killing effect cells, decrease cell survival rate 15%. carrier safety effectiveness delivery, treatment acute T lymphoblastic leukemia cells is obvious. perform well therapy, indicating drugs biological applicability new therapy.